Application

Silymarin has been used to study:its in vitro antiviral, antibacterial, antifungal activities and cytotoxicityits effect of silymarin on bladder contractions in cyclophosphamide (CYP)-induced cystitis rat model its effect on liver toxication induced by Fumonisin B1 in mice

Biochem/physiol Actions

Silymarin was shown to protect the liver from the cytotoxic effects of anti-tuberculosis drugs by decreasing serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) levels. This effect was related to the anti-oxidant effects of silymarin.

Silymarin is originally known to protect liver from various toxic agents and is used in treating hepatitis and cirrhosis. Silymarin possesses many biological actions such as antifibrotic, anti-lipid peroxidative, anti-inflammatory, immunomodulatory and membrane stabilizing. Silymarin also aids in liver regeneration.

Silymarin provides cardioprotective activity against ischemia-reperfusion induced myocardial infarction in rats.

General description

Silymarin is a flavonolignan, obtained from milk thistle (Silybum marianum) plant.

Other Notes

Mixture of anti-hepatotoxic flavonolignans from the fruit of Silybum marianum.