Application

Sonic hedgehog peptide from mouse has been used for neural differentiation.

Biochem/physiol Actions

Sonic hedgehog (Shh) has a role in fracture healing and regeneration. The protein associates with its receptor Patched (Ptc-1), de-represses Smoothened (Smo) and activates the Gli family of transcription factors. Mutations in the Shh pathway have been linked to developmental diseases and cancer.

Cell signaling peptide involved in embryonic morphogenic development of several tissues including Hensen′s node, the notochord, and the neural tube.

General description

Sonic hedgehog (Shh) is a morphogenic glycoprotein. The gene encoding it is localized on mouse chromosome 5.

Other Notes

N-terminal peptide encoding amino acid residues 25-198.

Physical form

Lyophilized from a 0.2 µm filtered solution in phosphate buffered saline, pH 7.4, containing 5% trehalose and 50 µg of bovine serum albumin per 1 µg of cytokine.