Application

4-Chloro-L-phenylalanine (L-PCPA) has been used: to block serotonin synthesis by inhibiting tryptophan hydroxylase (TPH) to study its behavioral and electrographic effects on epileptic senegalese baboon (Papio papio) as a substrate for Chromobacterium violaceum phenylalanine hydroxylaseto incubate sea urchin embryos for immunohistochemistry

Biochem/physiol Actions

4-Chloro-L-phenylalanine (L-PCPA) inhibits the synthesis of 5-hydroxytryptamine (5-HT). 4-Chloro-DL-phenylalanine (PCPA) depletes the serotonin levels in the brain by its inhibitory effect on tryptophan hydroxylase (Tph). Studies support the protective effects of PCPA against monocrotaline-induced pulmonary vascular remodeling as well as in lung inflammation.

Tryptophan hydroxylase inhibitor.

Packaging

1 g in glass bottle

250 mg in glass bottle

Bottomless glass bottle. Contents are inside inserted fused cone.