Biochem/physiol Actions

BCA-1 is a potent chemoattractant for B lymphocytes, but not T lymphocytes, monocytes, or neutrophils. Its specific receptor BLR1 is a G protein-coupled receptor originally isolated from Burkitt′s lymphoma cells. Among cells of the hematopoietic lineages, the expression of BRL1, now designated CXCR5, is restricted to B lymphocytes and a subpopulation of T helper memory cells.

The biological activity of human BLC/BCA-1 is measured by its ability to chemoattract mouse BaF/3 cells transfected with human CXCR5.

BCA-1 is a potent chemoattractant for B lymphocytes, but not T lymphocytes, monocytes, or neutrophils.

Physical form

Lyophilized from a 0.2 µm filtered solution in 35% acetonitrile and 0.1% TFA containing 50 µg bovine serum albumin per 1 µg of cytokine.