Application

Methyl 4-hydroxybenzoate has been used:in sex-linked recessive lethal (SLRL) test in Drosophila melanogasteras a constituent in cream formulationas an antifungal agent in Drosophila melanogaster culture

Biochem/physiol Actions

Methyl 4-hydroxybenzoate, also called methyl paraben or nipagin, comprises the ester of p-hydroxybenzoic acid. It is present naturally in cloudberry, white wine and bourbon vanilla. Methyl 4-hydroxybenzoate has antimicrobial and antifungal functionality and is commercially used as a preservative in the food, cosmetic and pharmaceutical industry. Methyl 4-hydroxybenzoate has cytotoxic effects on keratinocytes in the presence of sunlight. Methyl 4-hydroxybenzoate upon solar irradiation mediates DNA damage and modulates esterase metabolism resulting in skin damage and favors cancer progression. Methyl 4-hydroxybenzoate has estrogenic functionality and upregulates estrogen-related genes.

Legal Information

ReagentPlus is a registered trademark of Sigma-Aldrich Co. LLC

Packaging

5 kg in poly drum

100, 500 g in poly bottle

1 kg in poly bottle