The acute toxicity of aniline involves its activation in vivo to 4-hydroxyaniline and the formation of adducts with hemoglobin. In erythrocytes, this is associated with the release of iron and the accumulation of methemoglobin and the development of hemolytic anemia and inflammation of the spleen. Tumor formation is often observed in the spleen on prolonged administration.

Aniline is an aromatic primary amine that may be used as a reactant in the synthesis of organic intermediates such as 3-chloro-N-phenyl-pyridin-2-amine, (Z)-methyl 3-(phenylamino)but-2-enoate, 2-iodo-N-phenylbenzamide, 2,4-dichloroquinoline and N-(2-propynyl)aniline.

• CAS Number: 62-53-3
• Linear Formula: C6H5NH2
• Molecular Weight: 93.13
• Beilstein Registry Number: 605631
• EC Number: 200-539-3
• MDL Number: MFCD00007629
• eCl@ss: 39030407
• PubChem Substance ID: 24854547
• Grade: ACS reagent
• Vapor Density: 3.22 (185 °C, vs air)
• Vapor Pressure: 0.7 mmHg ( 25 °C)
• InChI Key: PAYRUJLWNCNPSJ-UHFFFAOYSA-N
• Assay: =99.5%
• Form: Liquid
• Autoignition Temp.: 1139 °F
• Expl. Lim.: 11 %
• Impurities: Hydrocarbons, passes test, Nitrobenzene, passes test (lim. ~0.001%), =0.01% chlorobenzene
• Ign. Residue: =0.005%
• Colour: APHA: =250, darkens in storage to reddish-brown with no loss in purity
• Refractive Index: n20/D 1.586(lit.)
• bp: 184 °C(lit.)
• mp: -6 °C (lit.)
• Solubility: Water: soluble
• Density: 1.022 g/mL at 25 °C(lit.)