Application

p-Toluenesulfonyl chloride may be used in the following processes:In combination with N-methylimidazole for the esterification or thioesterification of carboxylic acids and alcohols or thiols.As an additive to enhance the yield of symmetrical biaryls via palladium chloride catalyzed homo-coupling of arylboronic acids in the absence of ligands.As a positive chlorine source for the ?-chlorination of ketones.Solvent-free tosylation of alcohols and phenols in the presence of heterodoxy acids.As an activator for reaction between 2-alkynylbenzaldoxime and phenolsto form 1-aroxyisoquinolines in the presence of silver triflate.As a catalyst for the solvent-free preparation of symmetrical bis(benzhydryl)ethers from benzhydrols.

General description

p-Toluenesulfonyl chloride is an organic sulfonyl chloride mainly used to convert hydroxyl groups into good leaving group by forming sulfonates.

Legal Information

ReagentPlus is a registered trademark of Sigma-Aldrich Co. LLC

Packaging

5 g in glass bottle

100, 500 g in poly bottle