Application

Inosine 5′-triphosphate trisodium salt has been used to investigate its influence on thechromosome aberrationrate, themitotic rate,sister-chromatid exchange(SCE) frequency, the proportion of first (X1), second (X2) and third (X3) divisionmetaphases of human peripheral lymphocytes.

Inosine 5′-triphosphate (ITP) is used in studies on the impact of deamination of ATP and GTP by various enzymes and chemical processes. ITP may be used as a substrate to study the specificity and kinetics of nucleoside-5′-triphosphatase and ATPase. ITP is also used to study activation of various ATPases and GTPases.

Biochem/physiol Actions

Inosine 5′-triphosphate (ITP) has the ability to support the initiation of effector system. It can prevent guanosine 5′-triphosphate (GTP) hydrolysis, that is catalysed by transducin (TD).ITP can proficiently induce secretion in permeabilized cells than GTP. Instead of GTP, ITP can be used for the initiation and the elongation steps of reovirus transcription. ITP can also replace GTP in the activation of G-protein.

Packaging

1 g in poly bottle

50, 100, 500 mg in poly bottle

Preparation Note

Prepared from Bacterial ATP