CM Sepharose Fast Flow is a weak cation exchanger based on the well established Sepharose Fast Flow ion exchange platform, extensively used for preparative protein separations in both research and industrial applications.

• Well-proven weak cation exchanger developed for industrial downstream processes
• Used extensively for capture and intermediate purification of a wide range of approved biopharmaceuticals
• The industry standard for ion exchange chromatography during recent decades
• High chemical stability allows for well proven CIP and sanitization protocols
• The hydrophilic nature of the base matrix ensures low levels of non-specific binding leading to low levels of host cell-derived impurities in the elution pool.

CM Sepharose Fast Flow is part of the Sepharose Fast Flow ion exchange platform, which has been the industrial standard for ion exchange chromatography during recent decades. It is composed of cross-linked, 6% agarose particles, with carboxymethyl (CM) weak cation exchange groups. CM Sepharose Fast Flow has high chemical stability, allowing well proven cleaning-in-place (CIP) and sanitization protocols. Scale-up with CM Sepharose Fast Flow is straight forward and the resin is available in a range of pre-packed process development tools.

As member of the BioProcess resin range, CM Sepharose Fast Flow meets industrial demands with security of supply and comprehensive technical and regulatory support.