(S)-(-)-Bay K8644, >=98% (HPLC), solid

Code: B133-5MG D2-231

Application

(S)-(-)-Bay K8644 has been used as a L-type calcium channel (LTCC) agonist in the suprachiasmatic nucleus (SCN) slices. It has also been used as a LTCC a...


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Application

(S)-(-)-Bay K8644 has been used as a L-type calcium channel (LTCC) agonist in the suprachiasmatic nucleus (SCN) slices. It has also been used as a LTCC agonist to induce arrhythmiain rats.

Biochem/physiol Actions

(S)-(-)-Bay K8644 enhances Ca2+ current, whereas the (+)-Bay K 8644 is a weak Ca2+ channel antagonist. Bay K 8644 is lipophilic and it effectively scavenges superoxide anions.

Features and Benefits

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

General description

(S)-(-)-Bay K8644, a dihydropyridine compound is a Ca2+channel activator. It is an enantiomer of Bay K 8644.

Legal Information

Manufactured and sold with the permission of Bayer AG.

Packaging

1, 5 mg in glass bottle

assay≥98% (HPLC)
coloryellow
formsolid
Gene Informationhuman ... ADORA3(140)rat ... Adora1(29290), Adora2a(25369)
InChI keyZFLWDHHVRRZMEI-ZDUSSCGKSA-N
InChI1S/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,13,20H,1-3H3/t13-/m0/s1
Quality Level100
SMILES stringCOC(=O)C1=C(C)NC(C)=C([C@H]1c2ccccc2C(F)(F)F)[N+]([O-])=O
solubilityH2O: slightly soluble, ethanol: soluble (Organic solutions are stable for at least 20 days at RT.)
storage temp.2-8°C
Code
Description
Unit Size
List Price
Qty
B133-1MG
(S)-(-)-Bay K8644, >=98% (HPLC), solid

Unit:1MG
List Price: £187.00
Source:List Price
ADD
Cas Number98625-26-4
This product has met the following criteria: