MabSelect is a BioProcess protein A resin for capturing monoclonal antibodies (mAbs) from large sample volumes.
- High-flow agarose matrix allows for high flow velocities at production scale enabling the processing of more than 10,000 L of feed in one working day.
- Oriented coupling of the ligand and optimized matrix gives high dynamic binding capacity, which reduces resin volume requirements.
- Low non-specific binding resulting in low levels of impurities in the product eluate pool
- BioProcess resin supported for industrial applications and well-established in approved processes.
- Resin fulfils industrial demands for security of supply, robust performance, and regulatory support.
Optimized for high capacity and throughput
The resin is based on a highly cross-linked agarose matrix with a recombinant protein A ligand. This ligand is engineered to favor an oriented coupling resulting in an affinity resin with enhanced binding capacity for IgG. The hydrophilic nature of the base matrix ensures low levels of non-specific binding leading to low levels of host cell-derived impurities in the elution pool. MabSelect is optimized for high capacity, throughput and to deliver a product pool that is high in purity and yield.
High purification factor in a single step
The recombinant Protein A ligand is expressed in E. coli and is free of components of mammalian origin. The specificity of binding to the Fc region of IgG is similar to that of native protein A giving a high purification factor in a single step. In addition, the high capacity and the novel base matrix make MabSelect an excellent choice for purification of mAbs at process scale.
Security and support
As a member of the BioProcess resins range, MabSelect meets industrial demands with security of supply and comprehensive technical and regulatory support.
This product has met the following criteria: