Application

Used in a new synthesis of the ABCD ring system of Camptothecin.

1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU) may be used:as catalyst for carboxylic acid esterification with dimethyl carbonate in the synthesis of duocarmycin and CC-1065 analogs as catalyst in aza-Michael addition and Knovenegal condensation reactionas base for dehalogenation of halogenated Diels-Alder adducts and the resulting activated 2,4-dienones were subjected to regio- and stereo-directed Michael additions, using Yamamoto′s reagent (CH₃Cu · BF₃)in a new synthesis of the ABCD ring system of Camptothecin

1,8-Diazabicyclo[5.4.0]undec-7-ene may be used as an catalyst for the dissolution and activation of cellulose by a reversible reaction of its hydroxyl groups with carbon dioxide. This dissolved cellulose system can be derivatized to form cellulose mixed esters.

Citation

An application review.

Features and Benefits

Strong hindered amine base.

General description

1,8-Diazabicyclo[5.4.0]undec-7-ene is a bicyclic amidine base. It is non-nucleophilic, sterically hindered, tertiary amine base in organic chemistry. It is reported to be superior to amine catalyst in Baylis-Hillman reaction. It promotes the methylation reaction of phenols, indoles and benzimidazoles with dimethyl carbonate under mild conditions.

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Packaging

25, 100, 500 g in glass bottle

2.5 kg in glass bottle