Analysis Note
The biological activity is measured by its ability to induce alkaline phosphatase production by ATDC5 chondrogenic cells.
Biochem/physiol Actions
Cellular responses to BMP-2 are mediated by the formation of hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors. BMPs stimulate angiogenesis by inducing the production of VEGF-A by osteoblasts. Human, mouse, and rat BMP-2 demonstrate 100% homology.
Physical form
Lyophilized from a 0.2 µm filtered buffered solution containing 0.5 mg bovine serum albumin.
This product has met the following criteria: